Short-term effect of atorvastatin on carotid artery elasticity: a pilot study
| Autor: | Jose Gutierrez, Dalia Lorenzo, Janet T. DeRosa, David Della-Morte, Tatjana Rundek, Mitchell S.V. Elkind, Ralph L. Sacco, Mark S. McClendon, Elizabeth V Ratchford |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Atorvastatin Diastole Pilot Projects Settore MED/09 Article statins Right Common Carotid Artery carotid arteries Internal medicine medicine Humans Pyrroles Elasticity (economics) Aged Ultrasonography Aged 80 and over Advanced and Specialized Nursing Surrogate endpoint business.industry Ultrasound carotid ultrasound Repeated measures design Middle Aged Treatment Outcome Blood pressure Cardiovascular Diseases Heptanoic Acids Cardiology Female elasticity Neurology (clinical) Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business medicine.drug |
| Popis: | Background and Purpose— Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods— The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter−diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results— Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06–0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04–0.06; P P Conclusions— Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis. |
| Databáze: | OpenAIRE |
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