Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A
Autor: | Fabienne Proamer, Karène Mahtouk, Emmanuelle Meugnier, Maurizio Aricò, Christine Delprat, Cyrille Debard, Daniel Hanau, Nathalie Bernoud-Hubac, Nathalie Bissay, Giulia Salvatore, Patricia Daira, Hubert Vidal |
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Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), (France) CNRS, INSERM, Universite de Lyon 1, Institut Universitaire de France, Fondation pour l'Innovation et la Valorisation en Infectiologie, ANR Microbiologie-Immunologie-Environnement, LyonBiopole, Etablissement Francais du Sang EFS-Alsace, ARMESA (Association de Recherche et de Developpement en Medecine et Sante Publique), (Italy) Associazione Italiana Ricerca Istiocitosi (AIRI), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biologie Moléculaire de la Cellule (LBMC), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Analyses de Biologie Médicale (LABM), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS Alsace, Biologie des Cellules Dendritiques Humaines, EFS-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Onco-Hematology, A.Meyer Children's Hospital, Université de Lyon, Institut de recherche en biothérapie (IRB), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Delprat, Christine, Mahtouk, Karène |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Macrophages/immunology/metabolism
Cellular differentiation [SDV]Life Sciences [q-bio] immunology monocytes inflammation microarrays lipidomics interleukin 17A lipid immunometabolism Cell Differentiation/genetics Lipid Droplets/immunology/metabolism Inflammation Foam Cells/metabolism Biology Biochemistry Interleukin-17/genetics/immunology/*metabolism Proinflammatory cytokine chemistry.chemical_compound Cell Proliferation/genetics Endocrinology Lipid droplet medicine Oil Red O Humans T-Lymphocytes/immunology/metabolism cytokine proinflammatoire pathogénèse Liver X receptor maladie inflammatoire ComputingMilieux_MISCELLANEOUS Monocytes/immunology/metabolism Atherosclerosis/immunology/*metabolism/pathology Fatty Acids/*metabolism Lipid metabolism Cell Biology Dendritic Cells/immunology/*metabolism 3. Good health Cell biology chemistry Gene Expression Regulation Immunology Orphan Nuclear Receptors/biosynthesis/metabolism lipids (amino acids peptides and proteins) Interleukin 17 medicine.symptom Lipid Metabolism/immunology |
Zdroj: | Journal of Lipid Research Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2015, 56 (6), pp.1110-22. ⟨10.1194/jlr.M054874⟩ Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2015, 56 (6), pp.1110-1122 Journal of Lipid Research 6 (56), 1110-1122. (2015) |
ISSN: | 0022-2275 |
Popis: | International audience; Interleukin 17A (IL-17A) is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases. In the field of immunometabolism, we have studied the impact of IL-17A on the lipid metabolism of human in vitro-generated monocyte-derived dendritic cells (DCs). Microarrays and lipidomic analysis revealed an intense remodeling of lipid metabolism induced by IL-17A in DCs. IL-17A increased 2-12 times the amounts of phospholipids, cholesterol, triglycerides, and cholesteryl esters in DCs. Palmitic (16:0), stearic (18:0), and oleic (18:ln-9c) acid were the main fatty acid chains present in DCs. They were strongly increased in response to IL-17A while their relative proportion remained unchanged. Capture of extracellular lipids was the major mechanism of lipid droplet accumulation, visualized by electron microscopy and Oil Red O staining. Besides this foamy phenotype, IL-17A induced a mixed macrophage-DC phenotype and expression of the nuclear receptor NR1H3/liver X receptor-alpha, previously identified in the context of atherosclerosis as the master regulator of cholesterol homeostasis in macrophages. These IL-17A-treated DCs were as competent as untreated DCs to stimulate allogeneic naive T-cell proliferation. Following this first characterization of lipid-rich DCs, we propose to call these IL-17A-dependent cells "foamy DCs" and discuss the possible existence of foamy DCs in atherosclerosis, a metabolic and inflammatory disorder involving IL-17A. |
Databáze: | OpenAIRE |
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