Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation
| Autor: | Gul Shahnaz, Gul Majid Khan, Sarwat Jahan, Muhammad Farhan Sohail, Muhammad Rafay, Muhammad Tausif Chaudhry, Maria Hassan Kiani, Masoom Yasinzai, Jeand Baloch, Hafiz Shaib Sarwar |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject Administration Oral Biological Availability self-nanoemulsifying drug delivery system (SNEDDS) Pharmacology Article chemistry.chemical_compound Drug Delivery Systems Pharmacokinetics In vivo medicine Animals Chlorpromazine chlorpromazine media_common long-chain triglycerides lcsh:R5-920 Triglyceride business.industry General Medicine In vitro Rats Bioavailability Disease Models Animal chemistry oral bioavailability Emulsifying Agents solubility enhancement Drug delivery pharmacokinetics business lcsh:Medicine (General) medicine.drug |
| Zdroj: | Medicina, Vol 55, Iss 5, p 210 (2019) Medicina Volume 55 Issue 5 Medicina; Volume 55; Issue 5; Pages: 210 |
| Popis: | Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous solubility&mdash with extensive first-pass metabolism&mdash can be a suitable candidate for the development of SNEDDS. The current study was designed to develop triglyceride-based SNEDDS of chlorpromazine to achieve improved solubility, stability, and oral bioavailability. Materials and Methods: Fifteen SNEDDS formulations of each short, medium, and long chain, triglycerides were synthesized and characterized to achieve optimized formulation. The optimized formulation was characterized for several in vitro and in vivo parameters. Results: Particle size, zeta potential, and drug loading of the optimized SNEDDS (LCT14) were found to be 178 ± 16, &minus 21.4, and 85.5%, respectively. Long chain triglyceride (LCT14) showed a 1.5-fold increased elimination half-life (p < 0.01), up to 6-fold increased oral bioavailability, and 1.7-fold decreased plasma clearance rate (p < 0.01) compared to a drug suspension. Conclusion: The findings suggest that SNEDDS based on long-chain triglycerides (LCT14) formulations seem to be a promising alternative for improving the oral bioavailability of chlorpromazine. |
| Databáze: | OpenAIRE |
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