DTI-derived indexes of brain WM correlate with cognitive performance in vascular MCI and small-vessel disease. A TBSS study
| Autor: | Emilia Salvadori, Stefano Ciulli, Francesca Lorenzini, Leonardo Pantoni, Mario Mascalchi, Marco Giannelli, Nicola Toschi, Andrea Ginestroni, Stefano Diciotti, Stefano Orsolini, Nicola De Stefano, Anna Poggesi, Antonio Giorgio, Marco Pasi, Domenico Inzitari |
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| Přispěvatelé: | Mascalchi, Mario, Salvadori, Emilia, Toschi, Nicola, Giannelli, Marco, Orsolini, Stefano, Ciulli, Stefano, Ginestroni, Andrea, Poggesi, Anna, Giorgio, Antonio, Lorenzini, Francesca, Pasi, Marco, de Stefano, Nicola, Pantoni, Leonardo, Inzitari, Domenico, Diciotti, Stefano |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Neuropsychological Tests Corpus callosum Corpus Callosum Behavioral Neuroscience Cognition 0302 clinical medicine Nuclear Medicine and Imaging Diffusion tensor imaging Mild cognitive impairment Montreal cognitive assessment Small vessel disease White matter Radiology Nuclear Medicine and Imaging Neurology Cognitive Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health Medicine medicine.diagnostic_test 05 social sciences Settore FIS/07 Neuropsychology Brain Montreal Cognitive Assessment Middle Aged Psychiatry and Mental health medicine.anatomical_structure Cardiology Female Radiology medicine.medical_specialty Cognitive neuroscience 050105 experimental psychology 03 medical and health sciences Internal medicine mental disorders Fractional anisotropy Humans Cognitive Dysfunction 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Aged Mini–Mental State Examination business.industry Anisotropy business 030217 neurology & neurosurgery Diffusion MRI |
| Popis: | Indexes derived from diffusion tensor imaging (DTI) are sensitive to changes of both T2-hyperintense and normal-appearing brain white matter (WM) in elderly subjects with variable cognitive status. We investigated correlations between global cognitive performance and DTI-derived indexes along the WM tracts in the brain of patients with vascular mild cognitive impairment (MCI) and small vessel disease (SVD). Seventy-six patients with vascular MCI and SVD were assessed through Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) test and underwent DTI examination on a 1.5 T MR scanner. We used Tract Based Spatial Statistics (TBSS) to assess voxel-wise in the entire brain the spatial distribution of the correlation between values of fractional anisotropy, mean, axial/radial diffusivity and global cognitive performance as assessed with MoCA and MMSE tests. All correlations were statistically tested with a significant p-value |
| Databáze: | OpenAIRE |
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