Contact Allergy to 4,4'-Dihydroxy-(hydroxymethyl)-diphenyl Methanes: Sensitizers in a Phenol-Formaldehyde Resin
| Autor: | Magnus Bruze, Erik Zimerson, Lena Persson, Sigfrid Fregert |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Serial dilution
Polymers Dermatology Mass spectrometry Dermatitis Contact High-performance liquid chromatography Biochemistry Mass Spectrometry Gel permeation chromatography chemistry.chemical_compound Phenols Phenol formaldehyde resin Formaldehyde Humans Hydroxymethyl Benzhydryl Compounds Molecular Biology Chromatography High Pressure Liquid Skin Tests chemistry.chemical_classification Ethanol Chemistry Cell Biology Allergens Occupational Diseases Contact allergy Nuclear chemistry |
| Zdroj: | Journal of Investigative Dermatology. 87(5):617-623 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12455862 |
| Popis: | A particular phenol-formaldehyde resin of the resol type (P-F-R-2) was shown in a previous study to be a good tracer of patients with contact allergy to phenol-formaldehyde resins. Eleven patients with sensitivity to P-F-R-2 participated in the study in which chromatographically separated fractions of P-F-R-2 were patch tested. This procedure was repeated until a positive reaction to a single substance was noted. In this study 3 new sensitizers are reported. Investigations by mass spectrometry and nuclear magnetic resonance spectrometry identified the compounds to be 4,4′-dihydroxy-3-(hydroxymethyl)-diphenyl methane (4,4′-H-3-HPM), 4,4′-dihydroxy-3,3′-di-(hydroxymethyl)-diphenyl methane (4,4′-H-3,3′-HPM), and 4,4′-dihydroxy-3,5-di-(hydroxymethyl)-diphenyl methane (4,4′-H-3,5-HPM). Six of the 11 patients reacted to at least one of these compounds. All 6 patients reacted to 4,4′-H-3,3′-HPM and 5 reacted simultaneously to 4,4′-H-3-HPM. Four patients reacted to all 3 compounds tested. By patch testing with serial dilutions (ethanol 99.5%) of the three 4,4′-H-HPM, positive reactions were noted down to 0.5 × 10 −6 %, 1.0 × 10 −6 %, and 1.3 × 10 −3 % w/v for 4,4′-H-3-HPM, 4,4′-H-3,3′-HPM, and 4,4′-H-3,5-HPM, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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