CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD
| Autor: | Peter Hermann, Isidro Ferrer Abizanda, Enric Vidal, Kaj Blennow, Henrik Zetterberg, Anna Villar-Piqué, Matthias Schmitz, Daniela Diaz-Lucena, André Karch, Franc Llorens, Inga Zerr |
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| Přispěvatelé: | Producció Animal, Sanitat Animal, HZI, Helmholtz Zentrum für Infektionsforschung, GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology Creutzfeldt-Jakob Syndrome Pathogenesis creutzfeldt-jakob disease pathology [Alzheimer Disease] 0302 clinical medicine Cerebrospinal fluid Neurofilament Proteins pathology [Brain] neurofilament light Medicine Neurogranin tau 0303 health sciences neurogranin Neurodegeneration neurodegenerative dementias diagnosis [Alzheimer Disease] Brain alzheimer’s disease cerebrospinal fluid [Creutzfeldt-Jakob Syndrome] cerebrospinal fluid [14-3-3 Proteins] cerebrospinal fluid [Alzheimer Disease] Psychiatry and Mental health cerebrospinal fluid [Biomarkers] Biomarker (medicine) Female medicine.medical_specialty Neurofilament light tau Proteins diagnosis [Creutzfeldt-Jakob Syndrome] cerebrospinal fluid 03 medical and health sciences Neuronal damage Alzheimer Disease mental disorders Humans ddc:610 030304 developmental biology Aged pathology [Creutzfeldt-Jakob Syndrome] Postmortem brain business.industry medicine.disease nervous system diseases cerebrospinal fluid [Neurofilament Proteins] 14-3-3 Proteins cerebrospinal fluid [tau Proteins] Case-Control Studies Surgery Neurology (clinical) cerebrospinal fluid [Neurogranin] business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry 90(8), 846-853 (2019). doi:10.1136/jnnp-2018-320155 IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) Journal of neurology, neurosurgery, and psychiatry England |
| DOI: | 10.1136/jnnp-2018-320155 |
| Popis: | ObjectiveTo investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer’s disease (AD), and associated with neuronal degeneration in brain tissue.MethodsCSF neurogranin, total tau, neurofilament light (NFL) and 14-3-3 protein were measured in neurological controls (NCs, n=64), AD (n=46) and CJD (n=81). The accuracy of neurogranin discriminating the three diagnostic groups was evaluated. Correlations between neurogranin and neurodegeneration biomarkers, demographic, genetic and clinical data were assessed. Additionally, neurogranin expression in postmortem brain tissue was studied.ResultsCompared with NC, CSF neurogranin concentrations were increased in CJD (4.75 times of NC; pConclusionsNeurogranin is a new biomarker of prion pathogenesis with diagnostic and prognostic abilities, which reflects the degree of neuronal damage in brain tissue in a CJD subtype manner. |
| Databáze: | OpenAIRE |
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