Benzene exposure at workplace and risk of colorectal cancer in four Nordic countries
| Autor: | Kristina Kjærheim, Johnni Hansen, Elisabete Weiderpass, Madar Talibov, Laufey Tryggvadottir, Per Sparen, Eero Pukkala, Jorma Sormunen, Jan Ivar Martinsen |
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| Přispěvatelé: | Department of Medical and Clinical Genetics, Medicum, University of Helsinki |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Occupational cancer Epidemiology Colorectal cancer Cohort Studies 0302 clinical medicine Workplace Aged 80 and over Occupation Exposure Category Incidence Absolute risk reduction Case-control study WORKERS MEN Middle Aged Prognosis 3142 Public health care science environmental and occupational health 3. Good health Occupational Diseases Oncology 030220 oncology & carcinogenesis Cohort Female Colorectal Neoplasms Adult medicine.medical_specialty 3122 Cancers Scandinavian and Nordic Countries 03 medical and health sciences Occupational Exposure Internal medicine COLON medicine Humans Ascending colon COHORT RECTAL-CANCER METAANALYSIS Aged business.industry MORTALITY Benzene Odds ratio medicine.disease 030104 developmental biology PHYSICAL-ACTIVITY Case-Control Studies business |
| Popis: | Objective The aim of this case-control study was to assess the effect of occupational benzene exposure on the risk of colorectal cancer, including its subtypes. Methods The study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway and Sweden. Cases were identified from the Nordic Occupational Cancer Study (NOCCA) cohort. Five controls per case were selected from the same cohort, matched for country, birth year, and sex. Occupational benzene exposure for each study participant was estimated by linking their job titles to country specific job-exposure matrices. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work, formaldehyde, ionizing radiation and wood dust. Results Increased risk was observed for all colorectal cancer (OR = 1.12, 95% CI 1.05–1.18) for the high decile of cumulative benzene exposure, indicating a statistically significant dose-response relationship. This excess risk was mainly seen in ascending colon (OR = 1.27, 95% CI 1.13–1.43), and transversal colon (OR = 1.21, 95% CI 1.01–1.41). The ORs in the highest exposure category were markedly higher in women than in men in all subsites of colon and rectum. Conclusion This study showed an association between workplace benzene exposure and colorectal cancer. The risk was restricted to ascending and transversal colon, and was the strongest among women. |
| Databáze: | OpenAIRE |
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