A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations
| Autor: | Maciej Banach, Simona Dragan, Maria-Corina Serban, Gheorghe Stoichescu-Hogea, Florina Andrica, Amirhossein Sahebkar, Sorin Ursoniu |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Databases Factual Low density lipoprotein cholesterol 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Animal science Total cholesterol Internal medicine Plasma lipids Spirulina Humans Medicine 030212 general & internal medicine Triglycerides Randomized Controlled Trials as Topic Spirulina (genus) Nutrition and Dietetics biology business.industry Cholesterol HDL Cholesterol LDL Glycosylated serum protein biology.organism_classification Endocrinology Meta-analysis Dietary Supplements Plasma concentration business Body mass index |
| Zdroj: | Clinical Nutrition. 35:842-851 |
| ISSN: | 0261-5614 |
| Popis: | The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma lipid concentrations.We searched PubMed and Scopus (up to July 03, 2015) to identify randomized controlled trials (RCTs) that investigate the effect Spirulina supplementation on plasma lipid concentrations. Meta-analysis and meta-regression were performed using random-effects models.Random-effect meta-analysis of data from 7 RCTs showed a significant effect of supplementation with spirulina in reducing plasma concentrations of total cholesterol (WMD: -46.76 mg/dL, 95% CI: -67.31 to -26.22, p 0.001), LDL-C (WMD: -41.32 mg/dL, 95% CI: -60.62 to -22.03, p 0.001) and triglycerides (WMD: -44.23 mg/dL, 95% CI: -50.22 to -38.24, p 0.001), and elevating those of HDL-C (WMD: 6.06 mg/dL, 95% CI: 2.37-9.76, p = 0.001). The impact of spirulina on plasma concentrations of total cholesterol (slope: -1.32; 95% CI: -8.58 to 5.93; p = 0.720), LDL-C (slope: -1.01; 95% CI: -8.03 to 6.02; p = 0.778), triglycerides (slope: -1.39; 95% CI: -4.26 to 1.48; p = 0.342) and HDL-C (slope: 1.79, 95% CI: -0.48 to 4.05; p = 0.122) was independent of administered dose. Regarding duration of supplementation with Spirulina, significant associations were found with changes in plasma concentrations of total cholesterol (slope: -1.77; 95% CI: -3.48 to -0.07; p = 0.042), LDL-C (slope: -1.73; 95% CI: -3.40 to -0.06; p = 0.042) HDL-C (slope: 0.91; 95% CI: 0.68-1.14; p 0.001) and triglycerides (slope: -1.39; 95% CI: -2.28 to -0.50; p = 0.002).This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C. |
| Databáze: | OpenAIRE |
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