Oral medication delivery in impaired swallowing: thickening liquid medications for safe swallowing alters dissolution characteristics
| Autor: | Kathryn J. Steadman, Jason R. Stokes, Yady J. Manrique, Arron M. Sparkes, Julie A. Y. Cichero, Lisa Nissen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Pharmaceutical Population Pharmaceutical Science Administration Oral 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Swallowing Suspensions Oral administration Polysaccharides Drug Discovery medicine Humans 030212 general & internal medicine education Acetaminophen Pharmacology education.field_of_study business.industry Viscosity digestive oral and skin physiology Organic Chemistry Polysaccharides Bacterial Water Elixir Maltodextrin Dysphagia Deglutition Drug Liberation chemistry Solubility Anesthesia medicine.symptom business Deglutition Disorders Rheology Xanthan gum medicine.drug Tablets |
| Zdroj: | Drug development and industrial pharmacy. 42(9) |
| ISSN: | 1520-5762 |
| Popis: | Acetaminophen (paracetamol) is available in a wide range of oral formulations designed to meet the needs of the population across the age-spectrum, but for people with impaired swallowing, i.e. dysphagia, both solid and liquid medications can be difficult to swallow without modification. The effect of a commercial polysaccharide thickener, designed to be added to fluids to promote safe swallowing by dysphagic patients, on rheology and acetaminophen dissolution was tested using crushed immediate-release tablets in water, effervescent tablets in water, elixir and suspension. The inclusion of the thickener, comprised of xanthan gum and maltodextrin, had a considerable impact on dissolution; acetaminophen release from modified medications reached 12-50% in 30 min, which did not reflect the pharmacopeia specification for immediate release preparations. Flow curves reflect the high zero-shear viscosity and the apparent yield stress of the thickened products. The weak gel nature, in combination with high G' values compared to G'' (viscoelasticity) and high apparent yield stress, impact drug release. The restriction on drug release from these formulations is not influenced by the theoretical state of the drug (dissolved or dispersed), and the approach typically used in clinical practice (mixing crushed tablets into pre-prepared thickened fluid) cannot be improved by altering the order of incorporation or mixing method. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |