Staying at the crossroads: assessment of the potential of serum lithium monitoring in predicting an ideal lithium dose
| Autor: | Thiago Zaqueu Lima, Miriam Marcela Blanco, Luiz E. Mello, Jair Guilherme dos Santos Junior, Carolina Tesone Coelho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Elevated plus maze Bipolar Disorder Lithium (medication) Open field chemistry.chemical_compound Therapeutic index Antimanic Agents Test/anxiety Internal medicine medicine Animals Bipolar disorder Rats Wistar Maze Learning Serum/lithium levels Analysis of Variance business.industry Brain medicine.disease Surgery Rats Open field test Psychiatry and Mental health Endocrinology Lithium chloride Brain/lithium levels chemistry Female Analysis of variance business Lithium Dose Lithium Chloride medicine.drug |
| Zdroj: | Brazilian Journal of Psychiatry v.30 n.3 2008 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
| Popis: | OBJECTIVE: Lithium has been successfully employed to treat bipolar disorder for decades, and recently, was shown to attenuate the symptoms of other pathologies such as Alzheimer's disease, Down's syndrome, ischemic processes, and glutamate-mediated excitotoxicity. However, lithium's narrow therapeutic range limits its broader use. Therefore, the development of methods to better predict its dose becomes essential to an ideal therapy. METHOD: the performance of adult Wistar rats was evaluated at the open field and elevated plus maze after a six weeks treatment with chow supplemented with 0.255%, or 0.383% of lithium chloride, or normal feed. Thereafter, blood samples were collected to measure the serum lithium concentration. RESULTS: Animals fed with 0.255% lithium chloride supplemented chow presented a higher rearing frequency at the open field, and higher frequency of arms entrance at the elevated plus maze than animals fed with a 50% higher lithium dose presented. Nevertheless, both groups presented similar lithium plasmatic concentration. DISCUSSION: different behaviors induced by both lithium doses suggest that these animals had different lithium distribution in their brains that was not detected by lithium serum measurement. CONCLUSION: serum lithium concentration measurements do not seem to provide sufficient precision to support its use as predictive of behaviors. |
| Databáze: | OpenAIRE |
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