The Diagnostic Value of Integrated Growth Hormone Secretion Studies Shorter than 24 Hours in Normal- and Short-Growing Children
| Autor: | Zvi Zadik, Stuart A. Chalew, Avinoam Kowarski |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Percentile Time Factors Adolescent Endocrinology Diabetes and Metabolism Growth hormone Sensitivity and Specificity Endocrinology Reference Values Internal medicine medicine Humans Child Growth Disorders business.industry Blood collection Growth hormone secretion El Niño Evaluation Studies as Topic Child Preschool Growth Hormone Population study Female business GH Deficiency Provocative testing |
| Zdroj: | Hormone Research. 38:250-255 |
| ISSN: | 1423-0046 0301-0163 |
| Popis: | Spontaneous growth hormone (GH) secretion is evaluated by measurement of the 24-hour integrated concentration of GH (24-hour IC-GH), a major diagnostic procedure, or by shorter protocols such as monitoring 6 h during sleep. We have evaluated several possibilities for shortening the procedure by comparing the results of an abbreviated procedure to the 24-hour IC-GH studies. The study population consisted of 50 children with classic GH deficiency (group GHD), determined by provocative testing, and 45 children who had a subnormal secretion of GH (group N), determined by low 24-hour IC-GH but normal GH provocative tests. Twenty-two children of normal height and stature served as a control group. All the children were prepubertal, while there was no overlap between the lower 5th percentile of the 24-hour IC-GH of the control subjects (3.3 micrograms/l) and the upper 97th percentile of the 24-hour IC-GHs of the N and GHD groups (2.9 and 2.7 micrograms/l, respectively), there was a considerable overlap between the IC-GH of control subjects and that of the GHD and N groups measured in all the abbreviated blood withdrawal protocols, except for the 10-hour daytime and the 12-hour nighttime protocols of the GHD patients. It should be noted that there was only a small overlap between the control and the GHD groups during the 12-hour daytime protocol. We have found that the longer the blood collection period the greater the sensitivity and the specificity. We conclude that the 24-hour IC-GH test is the best diagnostic tool for identifying children with subnormal GH secretion. |
| Databáze: | OpenAIRE |
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