Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin
| Autor: | S Joshi, Panayotis G. Katsoyannis, Gerald P. Schwartz, G. Thompson Burke, Jai-Fang Wang, Matthew M. Rechler, Lucy Y.-H. Tseng, Zen Zen Chen, Maqsood Sheikh, S. Peter Nissley |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_treatment
Biophysics Chick Embryo Biochemistry Structure-Activity Relationship Insulin-like growth factor Somatomedins Insulin receptor substrate medicine Animals Humans Insulin Molecule Insulin-Like Growth Factor I Mitogenic activity Receptor Molecular Biology Chemistry Growth factor Receptors Somatomedin Embryo DNA Cell Biology Receptor Insulin Rats Insulin-Like Growth Factor Binding Proteins Mitogens Carrier Proteins |
| Zdroj: | Biochemical and Biophysical Research Communications. 149:672-679 |
| ISSN: | 0006-291X |
| Popis: | Two synthetic insulin-like compounds consisting of the B-chain of insulin linked via disulfide bonds to A chains corresponding to the A-domain or the A- and D-domains of insulin-like growth factor I (IGF-I) have been evaluated for mitogenic activity and for binding to IGF receptors and IGF carrier proteins. Both compounds are 3- to 5-fold more potent mitogens than insulin, and have a comparably increased affinity for the type I IGF receptor that mediates these mitogenic effects in chick embryo fibroblasts. Neither compound interacts with IGF carrier proteins. These results indicate that the A-domain of IGF-I is importantly involved in its growth-promoting properties. |
| Databáze: | OpenAIRE |
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