Genotoxicidad y evaluación histopatológica de nanopartículas de plata en ratones albinos suizos
| Autor: | Iyiola, Oluyinka. A., Olafimihan, Temitope F., Sulaiman, Faoziyat A., Anifowoshe, Abass T. |
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| Rok vydání: | 2018 |
| Předmět: |
silver nanoparticles
DNA damage genotoxicidad lcsh:A 010501 environmental sciences medicine.disease_cause 01 natural sciences Silver nanoparticle Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine morfología espermática micronúcleo medicine micronucleus Colchicine 030212 general & internal medicine 0105 earth and related environmental sciences histopathological nanopartículas de plata sperm morphology genotoxicity Sperm histopatológico medicine.anatomical_structure chemistry Micronucleus test Bone marrow lcsh:General Works Micronucleus Genotoxicity |
| Zdroj: | Cuadernos de Investigación UNED, Volume: 10, Issue: 1, Pages: 102-109, Published: JUN 2018 UNED Research Journal; Vol. 10 No. 1 (2018) UNED Research Journal; Vol. 10 Núm. 1 (2018) Portal de Revistas UNED Universidad Estatal a Distancia instacron:UNED Cuadernos de investigación UNED, Vol 10, Iss 1 (2018) |
| ISSN: | 1659-441X 1659-4266 |
| Popis: | Silver nanoparticles (AgNPs) are widely used in industrial and medical applications. However, there is a growing concern about the potentialities of AgNPs to induce genotoxicity and DNA damage in humans. In this study, genotoxic and histopathological effects of AgNPs were investigated in mice using two well-characterized genetic assays: mouse bone marrow micronuclei (MN) and mouse sperm morphology assays. Swiss albino mice (total N=18) were exposed to varying concentrations (3,000mg/Kg, 4,000mg/Kg, 5,000mg/Kg and 6,000mg/Kg) of AgNPs for 5 consecutive days and observed for 30 days afterwards. Distilled water and colchicine were used as negative and positive controls, respectively. The MN assay showed that the frequency of micronuclei induction increased with AgNP concentration. Statistically significant differences (p |
| Databáze: | OpenAIRE |
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