Streptococcus pneumoniae colonization in pneumococcal vaccine-naïve human immunodeficiency virus-exposed infected and -uninfected South African children
| Autor: | Teena Thomas, Shabir A. Madhi, Haseena Cassim, Charles D. Mitchell, Avy Violari, Sylvia Dittmer, Mark F. Cotton, Nadia van Niekerk, So Yeon Kim, Marta C. Nunes, Peter V. Adrian, Bret Zeldow |
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| Rok vydání: | 2020 |
| Předmět: |
Serotype
Male Adolescent medicine.drug_class Antibiotics Population Observational Study HIV Infections medicine.disease_cause Pneumococcal conjugate vaccine Pneumococcal Infections 03 medical and health sciences South Africa 0302 clinical medicine Streptococcus pneumoniae medicine Prevalence Humans Colonization 030212 general & internal medicine education Child carriage education.field_of_study Chi-Square Distribution business.industry Infant HIV General Medicine Nasal Lavage Fluid colonization Virology Penicillin Pneumococcal vaccine Influenza Vaccines 030220 oncology & carcinogenesis Child Preschool ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female business medicine.drug Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text Pneumococcal nasopharyngeal colonization is a pre-requisite for pneumococcal disease; the risk for pneumococcal disease is high in children born to women living with human immunodeficiency virus (HIV). We investigated pneumococcal colonization, serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae isolates carried by perinatal HIV-infected and HIV-exposed-uninfected (HEU) children. Serial nasopharyngeal swabs were collected from 331 HIV-infected and 491 HEU children, at up to 6 scheduled timepoints, between median ages of 25 to 181 weeks. Pneumococcus was identified by culture; serotyping and antibiotic susceptibility testing were done by conventional methods. No pneumococcal vaccine was given. HIV-infected children were less likely to be colonized with 7-valent pneumococcal conjugate vaccine 7 serotypes than HEU at a median of 25 weeks of age (23% vs 36%; P |
| Databáze: | OpenAIRE |
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