Extraordinary unremitting endurance exercise and permanent injury to normal heart

Autor:	W.J. Rowe
Rok vydání:	1992
Předmět:	medicine.medical_specialty Heart disease business.industry Ischemia Coronary Vasospasm Physical exercise General Medicine medicine.disease Surgery Catecholamines Endurance training Ventricular hypertrophy Risk Factors Internal medicine Coronary vasospasm medicine Cardiology Physical Endurance Humans Registries business Magnesium ion Exercise Magnesium Deficiency Coronary atherosclerosis
Zdroj:	Lancet (London, England). 340(8821)
ISSN:	0140-6736
Popis:	This hypothesis is that permanent cardiac injury could develop in some endurance athletes despite the absence of coronary atherosclerosis and ventricular hypertrophy. The proposed mechanism by which this injury could arise involves two physiological "vicious cycles". The first vicious cycle would occur between severe ischaemia and high catecholamines, the second would be between coronary vasospasm (induced by high catecholamines) and endothelial injury. The likelihood of the injury becoming permanent might increase if there is insufficient time between bouts of endurance exercise for regression of ischaemia and endothelial repair. Furthermore, magnesium ion deficiency, which can be induced by exercise, could exacerbate these vicious cycles and also contribute to catecholamine-induced thrombogenesis. In addition to ischaemia, there are several mechanisms, including the effect of free fatty acids liberated by the lipolytic effect of high catecholamines, that could cause direct myocardial injury.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd32d1c69deada38caeb6ddba6ca172 https://pubmed.ncbi.nlm.nih.gov/1357447 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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