Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance
Autor: | Moones Honarmand, Mehran Hosseini, Reyhane Javanshir, Mina Hemmati |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment lcsh:Medicine lcsh:RX1-681 02 engineering and technology Ziziphus jujube 010402 general chemistry medicine.disease_cause AuNPs 01 natural sciences chemistry.chemical_compound Insulin resistance Diabetes mellitus lcsh:Homeopathy Internal medicine medicine Vitamin D and neurology General Environmental Science Creatinine medicine.diagnostic_test business.industry Insulin lcsh:R Prooxidant antioxidant balance 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Endocrinology chemistry Urea General Earth and Planetary Sciences 0210 nano-technology business Lipid profile Oxidant/antioxidant status Oxidative stress |
Zdroj: | Clinical Phytoscience, Vol 6, Iss 1, Pp 1-10 (2020) |
ISSN: | 2199-1197 |
Popis: | Background Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Methods Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined. Results results showed a significant decrease in the level of liver MDA (P = 0.001), fasting blood glucose (P = 0.0001), HOMA-IR (P = 0.0001), ALT (P = 0.0001), AST (P = 0.0001), urea (P = 0.02), Triglycerides (P = 0.002), Total cholesterol (P = 0.0001), PAB (P = 0.0001) and AIP (P = 0.001) and in contrast a significant increase total antioxidant capacity (P = 0.02), insulin (P = 0.03), Body weight (P = 0.0001) and vitamin D (P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P = 0.18), LDL-C (P = 0.43), creatinine (P = 0.09) and HDL-C (P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats. Conclusion The results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties. |
Databáze: | OpenAIRE |
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