Glucagon secretion in anorexia nervosa
| Autor: | Tetsuya Nakagawa, M Kumai, Shinichi Fujii, Hajime Tamai, T T Aoki |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Anorexia Nervosa Time Factors medicine.medical_treatment media_common.quotation_subject Medicine (miscellaneous) Glucagon Impaired glucose tolerance Diabetes mellitus Internal medicine medicine Humans Insulin media_common Analysis of Variance Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test business.industry Glucagon secretion Appetite Glucose Tolerance Test medicine.disease Endocrinology medicine.anatomical_structure Female Energy Intake business Pancreas |
| Zdroj: | The American Journal of Clinical Nutrition. 47:239-242 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/47.2.239 |
| Popis: | Patients with anorexia nervosa frequently manifest impaired glucose tolerance. However, alterations in pancreatic glucagon secretion have also been associated with alterations in diabetes mellitus. For this reason, pancreatic alpha- and beta-cell responses to glucose load were measured in 25 anorexic patients both before and after treatment. The baseline glucose challenge failed to suppress plasma glucagon levels in the patients. However, in the control subjects and patients after treatment, glucagon levels were suppressed after glucose ingestion. Plasma glucose levels during the baseline challenge were significantly higher than those of the control subjects; however, after treatment glucose responses were nearly normal. Finally, insulin responses at baseline and after treatment were lower in the patients than in control subjects. These results suggest that the impaired glucose tolerance manifested by anorexic patients may be attributable to significant alterations in both pancreatic alpha- and beta-cell secretions and in pancreatic alpha-cell and glucose interrelationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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