INEFFECTIVENESS OF DIPYRIDAMOLE SPECT THALLIUM IMAGING AS A SCREENING TECHNIQUE FOR CORONARY ARTERY DISEASE IN PATIENTS WITH END-STAGE RENAL FAILURE
| Autor: | Donald Steinmuller, Raymundo T. Go, William E. Braun, Claudia Swift, Donald A. Underwood, Robert E. Hobbs, Thomas H. Marwick |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Population chemistry.chemical_element Coronary Disease Coronary Angiography Scintigraphy Coronary artery disease medicine Humans cardiovascular diseases education False Negative Reactions Aged Cardiac catheterization Transplantation education.field_of_study medicine.diagnostic_test business.industry Dipyridamole Middle Aged medicine.disease Thallium Radioisotopes chemistry Cardiovascular agent cardiovascular system Kidney Failure Chronic Thallium Female Radiology business Follow-Up Studies Tomography Emission-Computed medicine.drug |
| Zdroj: | Transplantation. 49:100-102 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199001000-00022 |
| Popis: | The efficacy of dipyridamole single photon emission computed tomography (SPECT) thallium as a screening test for coronary artery disease (CAD), was studied in 45 patients with end-stage renal failure undergoing evaluation for renal transplantation. Coronary arteriography, dipyridamole SPECT thallium imaging and clinical follow-up were performed in all patients. Nineteen patients (42%) had an obstruction of 50% or more in at least one coronary artery. Fourteen patients had a positive thallium scan, but 7 of these were false-positives (sensitivity 37%, specificity 73%). The sensitivity was considerably lower than that quoted for non-ESRF patients in the literature, and significantly lower than a control group of 19 patients without ESRF having comparable severity and distribution of CAD. Five of the 6 patients who died of cardiac causes over a mean follow-up period of 25 months had normal thallium imaging, but all had significant coronary artery disease at cardiac catheterization. Dipyridamole SPECT thallium imaging has not proved a useful screening test for angiographically significant CAD, and does not predict cardiac prognosis in this population. |
| Databáze: | OpenAIRE |
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