Augmented glucose production is not contingent on high catecholamines in fetal sheep with IUGR
| Autor: | Nathan R. Steffens, Amy C. Kelly, Andrew T. Antolic, Miranda J. Anderson, Alexander L. Pendleton, Sean W. Limesand, Melissa A. Davis, Rosa I. Luna-Ramirez, Leticia E. Camacho |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
0301 basic medicine congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucose uptake Intrauterine growth restriction 030209 endocrinology & metabolism Carbohydrate metabolism Article Fetal Development Norepinephrine 03 medical and health sciences Catecholamines Fetus 0302 clinical medicine Endocrinology Insulin resistance Pregnancy Internal medicine Adrenal Glands medicine Hyperinsulinemia Animals reproductive and urinary physiology Fetal Growth Retardation Sheep business.industry Insulin Biological Transport Placental Insufficiency medicine.disease female genital diseases and pregnancy complications Glucose 030104 developmental biology embryonic structures Gestation Female business |
| Zdroj: | J Endocrinol |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1530/joe-21-0071 |
| Popis: | Fetuses with intrauterine growth restriction (IUGR) have high concentrations of catecholamines, which lowers the insulin secretion and glucose uptake. Here, we studied the effect of hypercatecholaminemia on glucose metabolism in sheep fetuses with placental insufficiency-induced IUGR. Norepinephrine concentrations are elevated throughout late gestation in IUGR fetuses but not in IUGR fetuses with a bilateral adrenal demedullation (IAD) at 0.65 of gestation. Euglycemic (EC) and hyperinsulinemic–euglycemic (HEC) clamps were performed in control, intact-IUGR, and IAD fetuses at 0.87 of gestation. Compared to controls, basal oxygen, glucose, and insulin concentrations were lower in IUGR groups. Norepinephrine concentrations were five-fold higher in IUGR fetuses than in IAD fetuses. During the EC, rates of glucose entry (GER, umbilical + exogenous), glucose utilization (GUR), and glucose oxidation (GOR) were greater in IUGR groups than in controls. In IUGR and IAD fetuses with euglycemia and euinsulinemia, glucose production rates (GPR) remained elevated. During the HEC, GER and GOR were not different among groups. In IUGR and IAD fetuses, GURs were 40% greater than in controls, which paralleled the sustained GPR despite hyperinsulinemia. Glucose-stimulated insulin concentrations were augmented in IAD fetuses compared to IUGR fetuses. Fetal weights were not different between IUGR groups but were less than controls. Regardless of norepinephrine concentrations, IUGR fetuses not only develop greater peripheral insulin sensitivity for glucose utilization but also develop hepatic insulin resistance because GPR was maintained and unaffected by euglycemia or hyperinsulinemia. These findings show that adaptation in glucose metabolism of IUGR fetuses are independent of catecholamines, which implicate that hypoxemia and hypoglycemia cause the metabolic responses. |
| Databáze: | OpenAIRE |
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