Development of methionine-enkephalin in microdissected areas of the rabbit brain
| Autor: | J.L. Gingras-Leatherman, M.C. McNamara, Edward E. Lawson, Jau-Shyong Hong |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Telencephalon
medicine.medical_specialty Enkephalin Methionine Neuropeptide Nerve Tissue Proteins Biology Internal medicine medicine Animals Respiratory system Diencephalon Molecular Biology Depression (differential diagnoses) Brain Chemistry General Neuroscience Respiratory center Age Factors Brain Rabbit brain Methionine enkephalin Endocrinology Respiratory control Neurology (clinical) Brainstem Rabbits Developmental Biology Brain Stem |
| Zdroj: | Brain research. 336(1) |
| ISSN: | 0006-8993 |
| Popis: | Microdissected areas of the rabbit brain were isolated at prenatal day E-29, postnatal days P-3, 7, 14, 21, 2 months and adults. Methionine-enkephalin (ME) was assayed by RIA and ME concentration [ME] was expressed relative to the protein content of the extracted brain tissues. In brain nuclei with important roles in respiratory control [ME] was higher in prenatal and early postnatal life than in adults. In contrast, the prenatal and early postnatal [ME] levels in other nuclei were lower than or equal to adult values. These data suggest an important and changing role for ME in respiratory control throughout development. Early high [ME] levels within brainstem respiratory control nuclei may contribute to the newborn's increased susceptibility to respiratory depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|