Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease
| Autor: | Cai Mei Zheng, Bo Hau Chen, Wen Chih Liu, Kuo Cheng Lu, Po Jui Chen, Ta Chung Shen, Jenn Yeu Song, Jia-Feng Chang, Yi Chou Hou, Chien Lin Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Review Disease 030204 cardiovascular system & hematology Resveratrol resveratrol urologic and male genital diseases Gastroenterology Antioxidants lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Risk Factors cardiovascular disease lcsh:QH301-705.5 Spectroscopy Kidney Mortality rate General Medicine female genital diseases and pregnancy complications p-cresol sulfate Computer Science Applications medicine.anatomical_structure Cardiovascular Diseases medicine.medical_specialty Anemia trimethylamine-N-oxide Catalysis Inorganic Chemistry 03 medical and health sciences Internal medicine medicine microbiota Animals Humans Physical and Theoretical Chemistry Renal Insufficiency Chronic indoxyl sulfate Molecular Biology Vascular disease business.industry Organic Chemistry medicine.disease 030104 developmental biology chemistry lcsh:Biology (General) lcsh:QD1-999 Metabolic syndrome business chronic kidney disease Kidney disease |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6294, p 6294 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) and p-cresol sulfate (PCS)—produced in the liver by colonic microorganisms—cause kidney and vascular dysfunction. Plasma trimethylamine-N-oxide (TMAO)—a gut microbe-dependent metabolite of dietary L-carnitine and choline—is elevated in CKD and related to vascular disease, resulting in poorer long-term survival. Therefore, the modulation of colonic flora can improve prospects for patients with CKD. Managing metabolic syndrome, anemia, and abnormal mineral metabolism is recommended for the prevention of CVD in patients with CKD. Considering nontraditional risk factors, the use of resveratrol (RSV), a nutraceutical, can be helpful for patients with CVD and CKD. This paper discusses the beneficial effects of RSV on biologic, pathophysiological and clinical responses, including improvements in intestinal epithelial integrity, modulation of the intestinal microbiota and reduction in hepatic synthesis of IS, PCS and TMAO in patients with CVD and CKD. |
| Databáze: | OpenAIRE |
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