Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation
| Autor: | Paul Manohar, Samson W. Fine, Christopher Mow, Laurence A. Galea |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Adenocarcinoma Neuroendocrine differentiation Article World health Pathology and Forensic Medicine Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Carcinoma Humans Aged business.industry Transdifferentiation Prostatic Neoplasms Androgen Antagonists Cell Differentiation Prostate carcinoma medicine.disease Carcinoma Neuroendocrine 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Carcinoma Large Cell Surgery Anatomy business |
| Zdroj: | Int J Surg Pathol |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/10668969211035844 |
| Popis: | The 2016 World Health Organization classification of prostate cancer with neuroendocrine (NE) differentiation includes NE cells in usual prostate cancer, adenocarcinoma with Paneth cell-like NE differentiation, well-differentiated NE tumor (carcinoid), small cell NE carcinoma, and large cell NE carcinoma. In this article, we report a rare case of primary prostatic carcinoma with de novo diffuse NE differentiation presenting with bilateral hydronephrosis in a 79-year-old man. This case did not fit into any of the existing classifications. The clinical, radiological, morphological, and immunohistochemical findings and response to androgen deprivation therapy (ADT) are presented. The proposed pathogenesis of NE differentiation via transdifferentiation from conventional prostatic adenocarcinoma whereby genomic alterations, coupled with ADT can induce lineage plasticity resulting in NE differentiation is described. |
| Databáze: | OpenAIRE |
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