Functionalized Periodic Mesoporous Organosilica Nanoparticles for Loading and Delivery of Suramin
| Autor: | Vesna Kojić, Nikola Ž. Knežević, Djordje Janaćković, Sanja Djordjević |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
Suramin media_common.quotation_subject Nanoparticle Ethylenediamine 02 engineering and technology 010402 general chemistry 01 natural sciences cancer treatment Inorganic Chemistry chemistry.chemical_compound lcsh:Inorganic chemistry medicine Moiety media_common fungi 021001 nanoscience & nanotechnology Combinatorial chemistry lcsh:QD146-197 0104 chemical sciences 3. Good health Mesoporous organosilica chemistry Drug delivery drug delivery nanocarrier Nanocarriers porous nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Inorganics Volume 7 Issue 2 Inorganics, Vol 7, Iss 2, p 16 (2019) |
| ISSN: | 2304-6740 |
| DOI: | 10.3390/inorganics7020016 |
| Popis: | Suramin (SUR) is a known drug for treating parasitic infections though research studies and some clinical trials have shown its applicability for a plethora of other diseases. Herein we report on a novel SUR nanocarrier for the drug delivery to cells. We synthesized periodic mesoporous organosilica nanoparticles with spherical morphology, having mean diameter of 240 nm and high surface area (778 m2/g). The material&rsquo s surface is modified with an amine-containing organic moiety N-[3-(Trimethoxysilyl)propyl]ethylenediamine (DA), followed by surface attachment with the drug. The rate of SUR release in physiological condition was low, though in vitro experiments on MRC-5 cell line demonstrate effective delivery of the drug to the cells and low toxicity of the materials without the adsorbed drug. These results are promising for opening new treatment strategies with SUR-bearing nanocarriers, with high efficiency and low adverse effects on healthy tissues. |
| Databáze: | OpenAIRE |
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