Newly acquired peri-telomeric heterochromatin in a transgenic mouse lineage
| Autor: | D. Simon, B.B. Knowles |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Genetically modified mouse
Male Lineage (genetic) Heterochromatin Transgene Telomeric heterochromatin Mice Transgenic Biology Chromosomes Cell Line Mice Genetics Constitutive heterochromatin Animals Molecular Biology Genetics (clinical) Stem Cells Karyotype Telomere Molecular biology Chromosome Banding Pedigree Mice Inbred C57BL Chromosome 3 Karyotyping Female |
| Zdroj: | Cytogenetics and cell genetics. 62(4) |
| ISSN: | 0301-0171 |
| Popis: | Karyotypes of an embryonic stem cell line and normal bone marrow and peripheral blood cells from a transgenic mouse lineage, strain 83, exhibit a novel region of constitutive heterochromatin in the peri-telomeric region of chromosome 3. This heterochromatic region co-localizes with the integration site of the transgene, an 11-Mb tandem insertion of a plasmid containing human β-globin gene sequences, and is inherited in Mendelian fashion. The significance of this finding is discussed, and a nomenclature for such newly acquired heterochromatic regions is suggested. |
| Databáze: | OpenAIRE |
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