Placental Heat Shock Proteins: No Immunohistochemical Evidence for a Differential Stress Response in Preterm Labour
| Autor: | M.J. Divers, Judith N. Bulmer, David Miller, Richard J. Lilford |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Placenta Fight-or-flight response Andrology Obstetric Labor Premature Isomerism Pregnancy Heat shock protein Decidua Humans Medicine HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins Pregnancy Complications Infectious Heat-Shock Proteins reproductive and urinary physiology business.industry Obstetrics Preterm labour Obstetrics and Gynecology Bacterial Infections Chaperonin 60 Immunohistochemistry medicine.anatomical_structure Reproductive Medicine Female business |
| Zdroj: | Gynecologic and Obstetric Investigation. 40:236-243 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000292344 |
| Popis: | The aetiology of idiopathic preterm labour remains obscure. The hypothesis that a stress response induced by low-grade bacterial infection in utero-placental tissues was investigated. Distribution of cognate and inducible isoforms of heat shock proteins (HSP) 70 kD, HSP 60 kD and HSP 90 kD were investigated in an immunohistochemical study of placental and decidual tissues before and after labour at varying gestations. Subjects were pregnant women undergoing singleton delivery after idiopathic preterm labour at less than 34 weeks' gestation (n = 23); spontaneous term labour at 37-42 weeks' gestation (n =24); preterm caesarean sections at less than 34 weeks' gestation for preeclampsia or intrauterine growth retardation (n=14); elective caesarean section at 37-42 weeks' gestation for cephalopelvic disproportion (n = 6). HSP expression was constant throughout the third trimester of pregnancy and did not change following the onset of labour, regardless of gestational age. A stress response in decidual tissues as determined by immunohistochemical analysis is apparently not associated with preterm labour. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|