Fetal and neonatal exposure to the mycotoxin zearalenone induces phenotypic alterations in adult rat mammary gland
| Autor: | Sabine Balleydier, Claire Bellaton, Jean-François Mornex, Nadège Milhau, Jitka Durand, Magali Mure, Patrick Belli, Christian Le Jan, Mohamed Benahmed |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Mammary gland Apoptosis Biology Endocrine Disruptors Toxicology Andrology chemistry.chemical_compound Necrosis Fetus Mammary Glands Animal Pregnancy Internal medicine medicine In Situ Nick-End Labeling Endocrine system Animals Rats Wistar Zearalenone Cell Proliferation Endothelial Cells Cell Differentiation General Medicine Hyperplasia Mycotoxins medicine.disease Immunohistochemistry Rats medicine.anatomical_structure Endocrinology Phenotype chemistry Endocrine disruptor Animals Newborn In utero Toxicity Female Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 48(10) |
| ISSN: | 1873-6351 |
| Popis: | Zearalenone is a mycotoxin that is widespread in cereal food. We questioned whether this mycotoxin, administered during known critical exposure periods such as the fetal period and the first days of life, at doses compatible with mean daily intake in humans, could have an effect on mammary gland development in rodents. Wistar female rats were exposed to zearalenone (0.2 μg/kg to 5 mg/kg) during the last 14 days of fetal life and the first 5 post-natal days (PND). The mammary tissue was examined for development and maturation by morphologic analyses and immunochemistry. At PND 30, the mean length of terminal buds was significantly enhanced in all of the zearalenone-exposed females (p < 0.05). The mammary tissue, as evaluated by scoring of tissue slides, was significantly more differentiated in the 1 mg/kg treated group than in controls (p < 0.05). At PND 180, mammary tissue was more differentiated in all of the zearalenone treated groups (p < 0.05). At six months, 4 of 18 females exposed to 5 mg/kg of zearalenone presented mammary hyperplasia lesions. The induction of phenotypic alterations by zearalenone administered in utero and in the neonatal period at doses as low as 0.2 μg/kg suggests that zearalenone could contribute to the induction of breast endocrine disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect