Antagonism of the Inhibitory Effects of Transforming Growth Factor-? on Colony Formation of Mouse Bone Marrow Cells in Vitro by Increasing Concentrations of Growth Factors
| Autor: | I. Bertoncello, J. L. Millar, T. R. Bradley, R. L. Powles |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Alpha (ethology) Bone Marrow Cells Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Mice History and Philosophy of Science Transforming Growth Factor beta medicine Animals Growth Substances Cells Cultured Dose-Response Relationship Drug biology Interleukin-6 Chemistry Macrophage Colony-Stimulating Factor General Neuroscience Transforming growth factor beta Hematopoietic Stem Cells Molecular biology Recombinant Proteins In vitro medicine.anatomical_structure Colony formation Mice Inbred CBA biology.protein Interleukin-3 Bone marrow Antagonism Bone marrow progenitor cells Cell Division Interleukin-1 |
| Zdroj: | Annals of the New York Academy of Sciences. 628:52-58 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1991.tb17222.x |
| Popis: | Low concentrations of TGF-beta inhibited the clonal proliferation of three different preparations of mouse bone marrow progenitor cells in vitro. Normal marrow cells responsive to CSF-1; two-day post-fluorouracil cells responsive to CSF-1 plus IL-3 and IL-1 alpha; and regenerating seven-day post-fluorouracil cells responsive to CSF-1 plus IL-3, IL-1 alpha and IL-6 were all severely inhibited by TGF-beta 1; and the inhibitory effects were antagonized by increasing the concentrations of the relevant growth factors. |
| Databáze: | OpenAIRE |
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