Tetracycline improved the efficiency of other antimicrobials against Gram-negative multidrug-resistant bacteria
| Autor: | Victor Kuete, Isabelle Kamga Mawabo, J.-R. Kuiate, Jaurès A. K. Noumedem |
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| Rok vydání: | 2014 |
| Předmět: |
Multi drug resistant bacteria
Tetracycline medicine.drug_class Antibiotics Microbial Sensitivity Tests Pharmacology Biology lcsh:Infectious and parasitic diseases Microbiology Multi-drug-resistant bacteria Minimum inhibitory concentration Cloxacillin Ampicillin Drug Resistance Multiple Bacterial medicine Humans lcsh:RC109-216 Drug Interactions Bacteria Antimicrobials lcsh:Public aspects of medicine Chloramphenicol Public Health Environmental and Occupational Health lcsh:RA1-1270 General Medicine Bacterial Infections Antimicrobial Gram-negative Anti-Bacterial Agents Synergy Infectious Diseases medicine.drug |
| Zdroj: | Journal of Infection and Public Health, Vol 8, Iss 3, Pp 226-233 (2015) |
| ISSN: | 1876-035X |
| Popis: | Summary: Treatment of infectious diseases with antimicrobials constituted a great achievement in the history of medicine. Unfortunately, the emergence of resistant strains of bacteria to all classes of antimicrobials limited their efficacy. The present study was aimed at evaluating the effect of combinations of antibiotics on multi-drug resistant Gram-negative (MDRGN) bacteria.A liquid micro-broth dilution method was used to evaluate the antibacterial activity of 10 different classes of antimicrobials on 20 bacterial strains belonging to six different species. The antimicrobials were associated with phenylalanine β-naphthylamide (PAβN), an efflux pump inhibitor, and with other antimicrobials at their sub-inhibitory concentrations. The effectiveness of each combination was monitored using the minimal inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC).Most of the antimicrobials tested showed low antibacterial activity with a MIC value of 128 mg/L on a majority of the bacterial strains, justifying their multidrug-resistant (MDR) profile. Synergistic effects were mostly observed (FIC ≤ 0.5) when ampicillin (AMP), cloxacillin (CLX), erythromycin (ERY), chloramphenicol (CHL), kanamycin (KAN) and streptomycin (STR) were combined with tetracycline (TET) at the sub-inhibitory concentration of MIC/5 or MIC/10.The results of the present work suggest that the association of several antimicrobials with TET could improve the fight against MDRGN bacterial species. Keywords: Antimicrobials, Gram-negative, Multi-drug-resistant bacteria, Synergy, Tetracycline |
| Databáze: | OpenAIRE |
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