External Magnetic Field-Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles
| Autor: | Jie Yang, Qingpo Li, Chunqi Zhu, Yong-Zhong Du, Fenfen Kong, Xiaomeng Guo, Zuhua Wang, Wei Li, Jian You, Hanbo Zhang, Lihua Luo |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Dispersity Nanoparticle Tumor therapy Nanotechnology 02 engineering and technology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Magnetic field chemistry.chemical_compound chemistry Magnetic nanoparticles General Materials Science Particle size 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | ACS Applied Materials & Interfaces. 9:16581-16593 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.6b16513 |
| Popis: | The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance of an external magnetic field (MF), resulting in tumor-specific, targeted delivery. The behavior and magnetic-targeting efficiency of MNPs largely depend on their physiochemical properties, especially the particle size; however, the optimal size range may vary across the multiple bioapplications associated with multifunctional nanoparticles. The optimal size range of nanoparticles for external MF-mediated targeted delivery has rarely been reported. In this work, we synthesized a series of monodisperse Fe3O4 nanoparticles with identical surface properties ranging in size from 10 to 310 nm, and we systematically investigated their behavior and MF-assisted antitumor efficacy. Our data indicated that smaller Fe3O4 nanoparticles exhibited greater cellular internalization, while larger Fe3O4 nanoparticles showed greater tu... |
| Databáze: | OpenAIRE |
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