Ambulatory blood pressure profile in hypertensive patients with β-thalassemia minor
| Autor: | Gregory, Vyssoulis, Eva, Karpanou, Stella-Maria, Kyvelou, Vanessa, Tzamou, Athanasios, Triantafyllou, Andreas, Triantafyllou, George, Theodosiadis, Christodoulos, Stefanadis |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Thalassemia Minor Ambulatory blood pressure Physiology Anemia Group ii Essential hypertension Risk profile Cohort Studies Internal medicine Internal Medicine medicine Humans Myocardial infarction Aged Ultrasonography Greece business.industry beta-Thalassemia Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Circadian Rhythm Endocrinology Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 34(2) |
| ISSN: | 1348-4214 |
| Popis: | β-thalassemia trait (β-TT) is a common genetic disorder in Mediterranean countries, including Greece. Previous studies have shown the protective effect of β-TT against myocardial infarction. However, the ambulatory blood pressure (BP) profile of such patients has not yet been investigated. Thus, the purpose of the present study was to investigate the ambulatory BP monitoring (ABPM) profile of hypertensives with β-TT, in comparison with all-cause anemic and non-anemic essential hypertensive patients. The study ultimately comprised of 8861 essential hypertensive, nondiabetic patients who were divided into three groups: group I (n=191, with β-TT), group II (n=655, anemic) and group III (n=8015, nonanemic). All patients underwent full clinical, laboratory and echocardiographic evaluations, whereas all were subjected to ABPM. Anemia was defined as Hb12 g per 100 ml for women and13 g per 100 ml for men, whereas patients with β-TT were self-referred. The distribution of dipping patterns among the three groups was 61.3 vs. 41.2 vs. 45.8% (P0.001), whereas for nondippers it was 20.4 vs. 31.5 vs. 27.7% (P0.001), for extreme-dippers it was 15.7 vs. 15.0 vs. 17.5% (P0.001) and for reverse dippers it was 2.6 vs. 12.4 vs. 9.0% (P0.001). Furthermore, mean daytime systolic BP (SBP) among the three groups was 140.13 ± 7.79 vs. 142.02 ± 11.61 vs. 141.99 ± 9.87 mm Hg (P=0.03), and mean nighttime SBP was 125.87 ± 10.4 vs. 131.13 ± 15.7 vs. 129.62 ± 13.31 mm Hg (P0.001). In the multiple regression analysis, after adjustments for age, body mass index and lipid levels, the differences among daytime and nighttime SBP remained significant at 140.18 ± 9.84 vs. 142.02 ± 9.85 vs. 141.99 ± 9.85 mm Hg (P=0.04) and 125.99 ± 13.07 vs. 131.19 ± 13.08 vs. 129.61 ± 13.07 mm Hg (P0.001), respectively. Hypertensive patients with β-TT present with a better 24-h BP profile in comparison with anemic and nonanemic hypertensives. Thus, β-TT may function protectively in their total cardiovascular risk profile. |
| Databáze: | OpenAIRE |
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