Improvement of physicochemical and biopharmaceutical properties of theophylline by poly(ethylene glycol) coniugates
| Autor: | Marina Zacchigna, Francesca Cateni, Sonia Zorzet, G. Di Luca, V. Maurich |
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| Přispěvatelé: | Zacchigna, Marina, G., DI LUCA, Cateni, Francesca, Zorzet, Sonia, V., Maurich |
| Rok vydání: | 2003 |
| Předmět: |
Male
Active ingredient Aqueous solution Chemical Phenomena Chemistry Physical Chemistry Pharmaceutical Science Prodrug Biopharmaceutics Polyethylene Glycols Bioavailability chemistry.chemical_compound Theophylline Drug Discovery PEG ratio medicine Animals Organic chemistry Rabbits Drug carrier Ethylene glycol Nuclear chemistry medicine.drug |
| Popis: | In the present paper two theophylline esters with poly (ethylene glycol) (PEG) and methoxy poly (ethylene glycol) (mPEG) were prepared. Quantitative yields of the pure products were obtained. Unlike the free drug, the drug-polymer conjugates are freely water-soluble at room temperature. In vitro release experiments in aqueous buffer demonstrate that both conjugates are stable in buffer of pH 7.4 and 1.2. In vivo release studies after oral administration of theophylline conjugates demonstrate a good release of parent drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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