Morphogenesis of the bacterial division septum: a new class of septation-defective mutants
| Autor: | Ray A. Weigand, Kathleen D. Vinci, Lawrence Rothfield |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Salmonella typhimurium
Membranes Multidisciplinary Lipoproteins Cell Mutant Morphogenesis Biology Cell biology carbohydrates (lipids) Phenotype medicine.anatomical_structure Membrane Bacterial Proteins Solubility Covalent bond Cytoplasm Mutation medicine bacteria Free form Amino Acids Bacterial outer membrane Cell Division Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 73:1882-1886 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.73.6.1882 |
| Popis: | A new class of mutants of Salmonella typhimurium (lkyD mutants) are described. The mutants are defective in morphogenesis of the division septum, and are characterized by a failure of the outer membrane to invaginate despite normal ingrowth of the cytoplasmic membrane and murein layers of the growing septum. The cell envelopes of the mutants show a significant decrease in the bound form of murein-lipoprotein and a corresponding increase in the free form of the lipoprotein. This suggests that the morphogenic defect may result from a defect in formation of covalent bonds between the free lipoprotein of the outer membrane and the murein of the nascent septum. |
| Databáze: | OpenAIRE |
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