The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

Autor:	Jolanta Nawrot-Modranka, Marek Mirowski, Marta Michalska, Krzysztof Słomiak, Andrzej Łazarenkow
Rok vydání:	2017
Předmět:	0301 basic medicine Angiogenesis Basic fibroblast growth factor Angiogenesis Inhibitors General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Humans Receptor Fibroblast Growth Factor Type 1 Melanoma Hydrazine derivatives Cell Proliferation Cell growth Fibroblast growth factor receptor 2 Chemistry Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 3 Hydrazines 030104 developmental biology Chromones Cell culture 030220 oncology & carcinogenesis Cancer research Fibroblast Growth Factor 2 Drug Screening Assays Antitumor
Zdroj:	Acta Biochimica Polonica. 64:585-590
ISSN:	1734-154X 0001-527X
Popis:	The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbaeaf1ae74c41d4bcfee9726bf6776 https://doi.org/10.18388/abp.2017_1565 Zobrazit plný text záznamu