No evidence for a pathogen associated with pulmonary MALT lymphoma: a metagenomics investigation
Autor: | Bruno Crestani, Valérie Caro, Marianne Kambouchner, Christophe Hennequin, Véronique Hourdel, Martine Antoine, Karen Leroy, Jacques Cadranel, Mathias Vandenbogaert, Hilario Nunes, Raphael Borie, Aurélie Cazes, Christiane Copie-Bergman, Aurélia Kwasiborski |
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Přispěvatelé: | AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], Hôpital Avicenne [AP-HP], Service de pneumologie [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Anatomie et cytologie pathologiques [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hopital Saint-Louis [AP-HP] (AP-HP), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de chirurgie thoracique [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), This work was supported by Assistance Publique- Hôpitaux de Paris (CRC 2013-006 DRCI APHP) and by Roche., Service d’Anatomie et cytologie pathologiques [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gestionnaire, HAL Sorbonne Université 5 |
Rok vydání: | 2021 |
Předmět: |
Cancer Research
Epidemiology Short Report lcsh:RC254-282 [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Virus lcsh:Infectious and parasitic diseases Microbiology 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Medicine lcsh:RC109-216 Pathogen 030304 developmental biology 0303 health sciences Lung biology business.industry RNA virus MALT lymphoma Achromobacter xylosoxidans lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens biology.organism_classification medicine.disease 3. Good health Lymphoma Infectious Diseases Lymphatic system medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract business |
Zdroj: | Infectious Agents and Cancer Infectious Agents and Cancer, BioMed Central, 2021, 16 (1), ⟨10.1186/s13027-021-00351-w⟩ Infectious Agents and Cancer, 2021, 16 (1), ⟨10.1186/s13027-021-00351-w⟩ Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-4 (2021) |
ISSN: | 1750-9378 |
Popis: | Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin. Only one study suggested association between Achromobacter xylosoxidans and pulmonary MALT lymphoma. We aimed to investigate the presence of virus or any infectious agents in pulmonary MALT lymphoma by using metagenomic next-generation sequencing (mNGS).All lung samples were centrally reviewed. The t(11;18) (q21;q21) was evaluated by FISH analysis. The snap frozen large lung biopsies were analyzed by mNGS. After lung biopsies homogenization total nucleic acids (RNA and DNA) were extracted, amplified and classified according to their taxonomic assignment, after exclusion of host DNA.We included 13 samples from pulmonary MALT lymphoma (mean age: 60.3 years, 7 women, 3 with auto-immune background) and 10 controls. The diagnosis of MALT lymphoma was confirmed for the 13 samples, 3 showed API2-MALT1 translocation (23%). No evidence of the presence of a specific pathogen was clearly identified in the group of patients with pulmonary MALT lymphoma. We identifiedA. xylosoxidans sequence in 4/13 patients and in 4/10 controls.This study did not find evidence for a DNA or RNA virus, a fungi, a parasite or a bacteria associated with pulmonary MALT lymphoma either in the stroma or in tumor cells. |
Databáze: | OpenAIRE |
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