Effects of Euterpe oleracea to Enhance Learning and Memory in a Conditioned Nicotinic and Muscarinic Receptor Response Paradigm by Modulation of Cholinergic Mechanisms in Rats
| Autor: | Sule Aydin, Setenay Oner, Fatma Sultan Kilic, Cafer Yildirim, Basak Donertas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Euterpe Scopolamine Cholinergic Agents Medicine (miscellaneous) Morris water navigation task Pharmacology Mecamylamine Receptors Nicotinic Hippocampus 03 medical and health sciences 0302 clinical medicine Memory Muscarinic acetylcholine receptor medicine Hippocampus (mythology) Animals Rats Wistar Maze Learning Rivastigmine Memory Disorders 030109 nutrition & dietetics Nutrition and Dietetics Dose-Response Relationship Drug business.industry Receptors Muscarinic Acetylcholine Rats Nicotinic agonist 030220 oncology & carcinogenesis Analysis of variance business Full Communications medicine.drug |
| Zdroj: | J Med Food |
| Popis: | Euterpe oleracea (EO) includes a large number of polyphenolic compounds such as phenolics, flavonoids, and anthocyanins that have antioxidant activities. E. oleracea was suggested to ease the oxidative stress and inflammation in brain cells. Our aim was to analyze the effects of E. oleracea on learning and memory. Seventy-two (250 ± 25 g) male Wistar albino rats were used for this study. The groups consisted of control, EO100 mg/kg, EO300 mg/kg, scopolamine 1.5 mg/kg, mecamylamine 7.5 mg/kg, combinations of scopolamine with EO100 mg/kg, EO300 mg/kg, and rivastigmine 1.5 mg/kg; and mecamylamine combined with EO100 mg/kg. Before the start of the study, E. oleracea doses were provided once a day for a period of 15 days and for a 6-day experimental period. Thirty minutes after intraperitoneal scopolamine and mecamylamine injections, gastrogavage was applied to each group. Ninety minutes after the drug treatments, locomotor activity and Morris water maze tests were performed. Rats were killed and each hippocampus was used for the quantification of acetylcholine (Ach). Statistical analyses were calculated using one-way and two-way analyses of variance (ANOVA), and a value of P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|