Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
| Autor: | Chi Long Lin, S. Chattopadhyay, Yu Han Liu, Che Ming Jack Hu, Zih Syun Fang, Bing Yu Yao, Jung Chen Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Agonist
medicine.drug_class Antigen presentation Bioengineering Immunogenic Cell Death 02 engineering and technology Antineoplastic Agents Immunological Cell Line Tumor Neoplasms Medicine Cytotoxic T cell Animals Humans General Materials Science Mice Inbred BALB C business.industry Mechanical Engineering Nanoshells Membrane Proteins General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Sting Tumor progression Stimulator of interferon genes Cancer cell Cancer research Disease Progression Immunogenic cell death Immunotherapy 0210 nano-technology business |
| Zdroj: | Nano letters. 20(4) |
| ISSN: | 1530-6992 |
| Popis: | Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results in the release of endogenous danger signals along with tumor antigens for effective priming of anticancer immunity. We describe a strategy to artificially induce ICD by delivering the agonist of stimulator of interferon genes (STING) into tumor cells using hollow polymeric nanoshells. Following intracellular delivery of exogenous adjuvant, subsequent cytotoxic treatment creates immunogenic cellular debris that spatiotemporally coordinate tumor antigens and STING agonist in a process herein termed synthetic immunogenic cell death (sICD). sICD is indiscriminate to the type of chemotherapeutics and enables colocalization of exogenously administered immunologic adjuvants and tumor antigens for enhanced antigen presentation and anticancer adaptive response. In three mouse tumor models, sICD enhances therapeutic efficacy and restrains tumor progression. The study highlights the benefit of delivering STING agonists to cancer cells, paving ways to new chemo-immunotherapeutic designs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|