CORTISOL METABOLISM BY THE ISOLATED AND PERFUSED NEWBORN RABBIT LIVER

Autor:	L. Perletti, G. Sala, E. Castegnaro, F. Sereni
Rok vydání:	1966
Předmět:	medicine.medical_specialty Hydrocortisone Chromatography Paper Chemistry Endocrinology Diabetes and Metabolism Rabbit (nuclear engineering) In Vitro Techniques Perfusion Endocrinology Cortisol metabolism Animals Newborn Liver Adrenal Cortex Hormones Internal medicine medicine Animals Rabbits
Zdroj:	Journal of Endocrinology. 35:13-17
ISSN:	1479-6805 0022-0795
DOI:	10.1677/joe.0.0350013
Popis:	SUMMARY After perfusion of newborn rabbit liver with [1,2-3H]cortisol two radioactive metabolites were isolated from the perfusate and identified as 3α,11β,17α,21-tetrahydroxy-5β-pregnan-20-one (THF) and 11β,17α,20β,21-tetrahydroxypregn-4-en-3-one (20β-dihydrocortisol). The amount of metabolites recovered in the perfusate of livers of 1-day-old animals was lower than when 11- to 12-day-old animals were used. The results suggest a relative deficiency in the liver of newborn rabbits of the enzyme reducing ring A and the 20-oxo group of cortisol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb94db88b5ac03123fd41ac01363a41 https://doi.org/10.1677/joe.0.0350013 Zobrazit plný text záznamu