Influence of metoclopramide on abdominal wall healing in rats subjected to colonic anastomosis in the presence of peritoneal sepsis induced
| Autor: | Silvana Marques e Silva, Pedro Henrique Alves de Morais, Alexandre Malta Brandão, Marcos Vinícius Melo de Oliveira, Fabiana Pirani Carneiro, Naiara Galvão da Silva, João Batista de Sousa |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Time Factors Metoclopramide Colon Colonic anastomosis Anastomosis Fibrin Sepsis Abdominal wall Tensile Strength Surgical Wound Dehiscence medicine Animals Postoperative Period Rats Wistar Wound Healing biology business.industry Anastomosis Surgical Abdominal Wall medicine.disease Rats Disease Models Animal medicine.anatomical_structure Anesthesia biology.protein Dopamine Antagonists Surgery Foreign body Wound healing business medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.26 suppl.2 2011 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| Popis: | PURPOSE: To evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis. METHODS: 40 rats divided into two groups of twenty animals, subdivided into two subgroups of 10 animals each: group (E) - treated with metoclopramide, and saline-treated control group. The two groups were divided into subgroups of 10 to be killed on the 3rd day (n = 10) or day 7 (n = 10) after surgery. Sepsis was induced by cecal ligation and puncture. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. We measured the breaking strength of the abdominal wall and made the histopathological evaluation. RESULTS: on 3rd day postoperative, the average breaking strength in the E group was 0.83 ± 0.66 and in group C was 0.35 ± 0.46 (p = 0.010). On the seventh day, the breaking strength in group E was11.44 ± 5.07, in group C 11.66 ± 7.38 (p = 1.000). The E7 group showed lower inflammatory infiltration, foreign body reaction, fibrin than control. CONCLUSION: animals treated with metoclopramide had a higher resistance of the abdominal wall on the 3rd postoperative day. |
| Databáze: | OpenAIRE |
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