Autoantibody profile in a cohort of Algerian patients with systemic sclerosis
| Autor: | Azzedine Tahiat, Ines Allam, Réda Djidjik, A. Abdessemed, Rachid Nebbab, Yasmine Mellal, Aicha Ladjouze-Rezig |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Fluorescent Antibody Technique Disease Gastroenterology Scleroderma Cohort Studies Internal medicine Prevalence medicine Humans Clinical significance education Autoantibodies education.field_of_study Scleroderma Systemic business.industry Autoantibody Interstitial lung disease General Medicine Middle Aged Prognosis medicine.disease Algeria Cohort Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Annales de Biologie Clinique. 78:126-133 |
| ISSN: | 0003-3898 |
| Popis: | AIM To describe the autoantibody profile in a cohort of Algerian patients with systemic sclerosis (SSc) and to determine clinical associations between SSc-related autoantibodies, disease subtypes and specific clinical features. METHODS Consecutive Algerian patients with SSc were included in the present study. In addition to clinical characterization, all subjects underwent autoantibody testing using indirect immunofluorescence, immunoenzymatic, and line immunoblot assays. RESULTS A total of 150 patients were included in this study, 103 (68.7%) had limited cutaneous SSc (lcSSc), 42 (28%) had diffuse cutaneous SSc (dcSSc) and 5 (3.3%) had sine cutaneous scleroderma. One hundred thirty-five (90.0%) patients were positive for SSc-related autoantibodies, including 63 (42%) with more than one autoantibody. The two most frequent autoantibodies were anti-topoisomerase I (ATA) (76; 50.7%) and anti-SSA/Ro (49; 32.7%). Only 23 (15.3%) patients were positive for anticentromere; 9 (6%) were positive for anti RNA polymerase III; 5 (3.3%) for anti-U3 RNP; 3 (2%) for anti Th/To; 25 (16.7%) for anti-U1 RNP; 11 (7.3%) for anti-PM/Scl and 4 (2.7%) for anti-Ku. Anti-topoisomerase I was associated with dcSSc (p |
| Databáze: | OpenAIRE |
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