Chemotherapy and CDK4/6 Inhibition in Cancer Treatment: Timing Is Everything

Autor:	Anne Fassl, Piotr Sicinski
Rok vydání:	2020
Předmět:	0301 basic medicine Cancer Research DNA repair medicine.medical_treatment Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Humans Psychological repression Chemotherapy biology Cyclin-dependent kinase 4 business.industry Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Cell Biology medicine.disease Pancreatic Neoplasms 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell biology.protein Cancer research Cyclin-dependent kinase 6 CDK4/6 Inhibition business
Zdroj:	Cancer Cell. 37:265-267
ISSN:	1535-6108
Popis:	Chemotherapy remains the main treatment option for patients with several tumor types. In this issue of Cancer Cell, Salvador-Barbero et al. demonstrate that treatment with CDK4/6 inhibitors after application of taxanes (or other chemotherapeutic compounds) strongly potentiates the anti-tumor effect due to repression of DNA repair machinery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb8ee570b764b6b8ca4c932780fa3b8 https://doi.org/10.1016/j.ccell.2020.02.007 Zobrazit plný text záznamu