Randomized Trial of Plaque-Identifying Toothpaste: Decreasing Plaque and Inflammation
| Autor: | Kimberly L. Fasula, Benjamin Z. Belavsky, Patrick E. McBride, Lori Giblin, Linda D Boyd, Scott Hetzel, Carlotta A. Evans, David L. DeMets, Charles H. Hennekens |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty business.product_category Dental Plaque Dentistry Subgroup analysis Inflammation Placebo Dental plaque law.invention Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Risk Factors law Internal medicine Humans Medicine 030212 general & internal medicine Toothpaste business.industry Healthy subjects General Medicine medicine.disease Intention to Treat Analysis C-Reactive Protein Cardiovascular Diseases Female 030211 gastroenterology & hepatology medicine.symptom business Biomarkers Toothpastes |
| Zdroj: | The American Journal of Medicine. 130:746-749 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/j.amjmed.2016.09.003 |
| Popis: | Background Randomized data are sparse about whether a plaque-identifying toothpaste reduces dental plaque and nonexistent for inflammation. Inflammation is intimately involved in the pathogenesis of atherosclerosis and is accurately measured by high-sensitivity C-reactive protein (hs-CRP), a sensitive marker for cardiovascular disease. The hypotheses that Plaque HD (TJA Health LLC, Joliet, Ill), a plaque-identifying toothpaste, produces statistically significant reductions in dental plaque and hs-CRP were tested in this randomized trial. Methods Sixty-one apparently healthy subjects aged 19 to 44 years were assigned at random to this plaque-identifying (n = 31) or placebo toothpaste (n = 30) for 60 days. Changes from baseline to follow-up in dental plaque and hs-CRP were assessed. Results In an intention-to-treat analysis, the plaque-identifying toothpaste reduced mean plaque score by 49%, compared with a 24% reduction in placebo ( P = .001). In a prespecified subgroup analysis of 38 subjects with baseline levels >0.5 mg/L, the plaque-identifying toothpaste reduced hs-CRP by 29%, compared with a 25% increase in placebo toothpaste ( P = .041). Conclusion This plaque-identifying toothpaste produced statistically significant reductions in dental plaque and hs-CRP. The observed reduction in dental plaque confirms and extends a previous observation. The observed reduction in inflammation supports the hypothesis of a reduction in risks of cardiovascular disease. The direct test of this hypothesis requires a large-scale randomized trial of sufficient size and duration designed a priori to do so. Such a finding would have major clinical and public health implications. |
| Databáze: | OpenAIRE |
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