MicroRNAs and the HIF/VEGF axis in ocular neovascular diseases
| Autor: | Noemi Anna Pesce, Helder André, Flavia Plastino |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
genetic structures Angiogenesis Retinal Neovascularization 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine microRNA medicine Animals Humans business.industry Retinopathy of prematurity Retinal General Medicine Diabetic retinopathy Macular degeneration medicine.disease Choroidal Neovascularization eye diseases MicroRNAs Ophthalmology HIF1A Gene Expression Regulation chemistry Corneal neovascularization 030221 ophthalmology & optometry Cancer research Hypoxia-Inducible Factor 1 sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Acta Ophthalmologica. 99 |
| ISSN: | 1755-3768 1755-375X |
| Popis: | Ocular neovascular diseases, such as proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age-related macular degeneration, are the leading causes of visual impairment worldwide. The hypoxia-inducible factors and vascular endothelial growth factors are key molecular promoters of ocular neovascularization. Moreover, the role of microRNAs as regulators of angiogenesis has been expanding, particularly hypoxia-associated microRNA; hypoxamiRs. This review provides a summary of hypoxamiRs that directly and specifically target HIF1A and VEGF mRNAs, thus critically involved in the regulation of ocular neovascular pathologies. The discussed microRNAs highlight putative diagnostic markers and therapeutic agents in choroidal and retinal angiogenic diseases, including proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age-related macular degeneration. |
| Databáze: | OpenAIRE |
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