A new device for measuring spontaneous motor activity — Effects of lysergic acid diethylamide in rats

Autor:	Zdeněk Fink, Jan Kabeš, Zdeněk Roth
Rok vydání:	1972
Předmět:	Male Pharmacology Time Factors Chemistry Statistics as Topic Pharmacology toxicology Drug administration Motor Activity SMA Rats Automation Lysergic Acid Diethylamide Anesthesia Methods medicine Animals New device Motor activity Inhibitory effect Lysergic acid diethylamide medicine.drug
Zdroj:	Psychopharmacologia. 23:75-85
ISSN:	1432-2072 0033-3158
DOI:	10.1007/bf00414415
Popis:	By means of a new automatic apparatus the influence of lysergic acid diethylamide (LSD) on spontaneous motor activity (SMA) was investigated in rats. Both the horizontal and vertical component of SMA were registered simultaneously at various time intervals after i.p. administration of the drug. A biphasic effect of LSD on both parameters was observed—SMA was stimulated in the first phase, while an inhibitory effect appeared with the increasing interval from the drug administration. The horizontal component was found to be more sensitive to the stimulatory effect while inhibition was more marked in the vertical activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb5b44e3004ad02b19c1d28dead82ea https://doi.org/10.1007/bf00414415 Zobrazit plný text záznamu Full text from SpringerLink