3D-modeling of carboxyl-terminal phosphorylation of plant αβ-tubulin and its role in kinesin-8/microtubule interaction
| Autor: | Pavel Karpov, Oleh M. Demchuk, Yaroslav B. Blume |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Arabidopsis Kinesins macromolecular substances Biology Molecular Dynamics Simulation Microtubules 03 medical and health sciences Molecular dynamics Residue (chemistry) 0302 clinical medicine Protein structure Microtubule Tubulin Protein phosphorylation Kinesin 8 Phosphorylation Arabidopsis Proteins Cell Biology General Medicine 030104 developmental biology Biochemistry 030220 oncology & carcinogenesis biology.protein Protein Processing Post-Translational Protein Binding |
| Zdroj: | Cell biology internationalReferences. 43(9) |
| ISSN: | 1095-8355 |
| Popis: | The results of computer modeling of plant kinesin-8/αβ-tubulin complexes with such αβ-tubulins' modified amino acid residues as phosphorylated Tyr262 and Tyr107 are reported in this paper. The molecular dynamics of these modified complexes in comparison with the dynamics of non-modified ones suggests that the phosphorylation of both α- and β-tubulins reveals stabilizing effect on the protein structure around the modified residue. It was found also that the phosphorylation of Tyr107 in β-tubulin molecule favors to more advantageous kinesin-8 binding with the phosphorylated microtubule surface in terms of energy. |
| Databáze: | OpenAIRE |
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