Plasma Thyroid Hormone Concentration is Associated with Hepatic Triglyceride Content in Patients with Type 2 Diabetes
| Autor: | Nishanth E. Sunny, Srilaxmi Kalavalapalli, Romina Lomonaco, Kenneth Cusi, Diane Biernacki, Fernando Bril, Sushma Kadiyala, Amitabh Suman, Maryann Maximos, Paola Portillo Sanchez |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Severity of Illness Index General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Liver disease 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Diabetes mellitus Prevalence Humans Medicine Triglycerides Demography medicine.diagnostic_test business.industry Insulin Fatty liver nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Mitochondria Endocrinology Diabetes Mellitus Type 2 Liver Liver biopsy Female 030211 gastroenterology & hepatology Insulin Resistance business |
| Zdroj: | Journal of Investigative Medicine. 64:63-68 |
| ISSN: | 1708-8267 1081-5589 |
| Popis: | The underlying mechanisms responsible for the development and progression of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) are unclear. Since the thyroid hormone regulates mitochondrial function in the liver, we designed this study in order to establish the association between plasma free T4 levels and hepatic triglyceride accumulation and histological severity of liver disease in patients with T2DM and NAFLD. This is a cross-sectional study including a total of 232 patients with T2DM. All patients underwent a liver MR spectroscopy (1H-MRS) to quantify hepatic triglyceride content, and an oral glucose tolerance test to estimate insulin resistance. A liver biopsy was performed in patients with a diagnosis of NAFLD. Patients were divided into 5 groups according to plasma free T4 quintiles. We observed that decreasing free T4 levels were associated with an increasing prevalence of NAFLD (from 55% if free T4≥1.18 ng/dL to 80% if free T41H-MRS (p |
| Databáze: | OpenAIRE |
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