Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
| Autor: | Bart Jan Kullberg, Evangelos J. Giamarellos-Bourboulis, Daniela C. Ifrim, Liesbeth Jacobs, Jessica Quintin, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Hendrik G. Stunnenberg, Jos W. M. van der Meer, Sadia Saeed, Joost H.A. Martens, Ramnik J. Xavier, Colin Logie, Trees Jansen |
|---|---|
| Přispěvatelé: | Radboud University Medical Center [Nijmegen], Radboud university [Nijmegen], National and Kapodistrian University of Athens (NKUA), Jena University Hospital [Jena], University Medical Center Groningen [Groningen] (UMCG), Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
POLARIZATION Genetics and epigenetic pathways of disease [NCMLS 6] [SDV]Life Sciences [q-bio] MESH: Monocytes [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Monocytes ACTIVATION Mice NATURAL-KILLER-CELLS 0302 clinical medicine Candida albicans IMMUNE-RESPONSE MESH: Animals TRANSCRIPTION EPIGENETIC REGULATION Cells Cultured [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology 0303 health sciences MESH: Cytokines IMMUNOSUPPRESSION Candidiasis Health aging / healthy living Pathogenesis and modulation of inflammation [IGMD 5] Corpus albicans MESH: Candidiasis CROHNS-DISEASE 3. Good health Pathogenesis and modulation of inflammation [N4i 1] medicine.anatomical_structure [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology 030220 oncology & carcinogenesis Cytokines [SDV.IMM]Life Sciences [q-bio]/Immunology Female Reprogramming MESH: Cells Cultured Biology Invasive mycoses and compromised host Infection and autoimmunity [N4i 2] Microbiology DENDRITIC CELLS Article 03 medical and health sciences Immune system Immunity MESH: Mice Inbred C57BL Virology Immunology and Microbiology(all) medicine Animals Humans Lectins C-Type MESH: Mice Molecular Biology B cell 030304 developmental biology Innate immune system MESH: Humans Monocyte MESH: Candida albicans MEMORY Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] biology.organism_classification Mice Inbred C57BL Proto-Oncogene Proteins c-raf Immunology MESH: Proto-Oncogene Proteins c-raf Parasitology MESH: Female MESH: Lectins C-Type |
| Zdroj: | Cell Host & Microbe, 12, 2, pp. 223-232 Cell Host and Microbe Cell Host and Microbe, Elsevier, 2012, 12 (2), pp.223-232. ⟨10.1016/j.chom.2012.06.006⟩ Cell Host & Microbe, 12, 223-232 Cell Host & Microbe, 12(2), 223-232. CELL PRESS |
| ISSN: | 1934-6069 1931-3128 |
| DOI: | 10.1016/j.chom.2012.06.006 |
| Popis: | Item does not contain fulltext Immunological memory in vertebrates is often exclusively attributed to T and B cell function. Recently it was proposed that the enhanced and sustained innate immune responses following initial infectious exposure may also afford protection against reinfection. Testing this concept of "trained immunity," we show that mice lacking functional T and B lymphocytes are protected against reinfection with Candida albicans in a monocyte-dependent manner. C. albicans and fungal cell wall beta-glucans induced functional reprogramming of monocytes, leading to enhanced cytokine production in vivo and in vitro. The training required the beta-glucan receptor dectin-1 and the noncanonical Raf-1 pathway. Monocyte training by beta-glucans was associated with stable changes in histone trimethylation at H3K4, which suggests the involvement of epigenetic mechanisms in this phenomenon. The functional reprogramming of monocytes, reminiscent of similar NK cell properties, supports the concept of "trained immunity" and may be employed for the design of improved vaccination strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|