Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice
| Autor: | Laryssa Regis Bueno, Bruna da Silva Soley, Kahlile Youssef Abboud, Isabella Wzorek França, Karien Sauruk da Silva, Natalia Mulinari Turin de Oliveira, Juliana Santos Barros, Marcelo Biondaro Gois, Lucimara Mach Côrtes Cordeiro, Daniele Maria-Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Dietary Fiber
Inflammation Aging Article Subject Colon Interleukin-6 Passiflora Superoxide Dismutase Tumor Necrosis Factor-alpha Dextran Sulfate Cell Biology General Medicine Colitis Inflammatory Bowel Diseases Biochemistry Interleukin-10 Mice Inbred C57BL Mice Disease Models Animal Polysaccharides Fruit Animals Cytokines Colitis Ulcerative |
| Zdroj: | Oxidative Medicine and Cellular Longevity. |
| ISSN: | 1942-0900 |
| DOI: | 10.1155/2022/6298662 |
| Popis: | Inflammatory bowel disease (IBD) is a complex inflammatory disorder characterized by chronic and spontaneously relapsing inflammation of the gastrointestinal tract. IBD includes two idiopathic disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In particular, UC causes inflammation and ulceration of the colon and rectum. There is no cure for UC. The pharmacological treatment is aimed at controlling and/or reducing the inflammatory process and promoting disease remission. The present study investigated the possible protective effects of soluble dietary fiber (SDF) isolated from yellow passion fruit peel in the dextran sulfate sodium- (DSS-) induced colitis model in mice, induced by 5% of DSS. The animals were treated with SDF (10, 30, or 100 mg/kg (po)), and the disease activity index was monitored. Colon tissues were collected, measured, and prepared for oxidative stress, inflammation, and histology analysis. SDF improved body weight loss, colon length, and disease activity index and prevented colonic oxidative stress by regulating GSH levels and SOD activity. Furthermore, SDF reduced colonic MPO activity, TNF-α, and IL-1β levels and increased IL-10 and IL-6 levels. As observed by histological analysis, SDF treatment preserved the colonic tissue, the mucus barrier, and reduced inflammatory cell infiltration. Although this is a preliminary study, taken together, our data indicate that SDF may improve the course of DSS-UC. More studies are needed to explore and understand how SDF promotes this protection. |
| Databáze: | OpenAIRE |
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