Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men
| Autor: | Kelly J. Dix, Matthew A. Koch, Judith Hill, James A. Crowell, Tracy M. Black, LeAnne T Bloedon, Brian F. Thomas, William D. Heizer, Steven H. Zeisel, Marjorie G Busby, A. Robert Jeffcoat |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Diet therapy Medicine (miscellaneous) Genistein chemistry.chemical_compound Pharmacokinetics Internal medicine medicine Anticarcinogenic Agents Humans Estrogens Non-Steroidal Volume of distribution Nutrition and Dietetics Daidzein Area under the curve food and beverages Glycitein Isoflavones Endocrinology chemistry Soybeans Half-Life |
| Zdroj: | The American Journal of Clinical Nutrition. 75:126-136 |
| ISSN: | 0002-9165 |
| Popis: | Background: Soy isoflavones are potential cancer chemoprevention treatments. Objective: We conducted safety studies of purified unconjugated genistein, daidzein, and glycitein, and defined pharmacokinetic parameters for their absorption and metabolism. Design: Thirty healthy men ingested a single dose of 1 of 2 isoflavone preparations purified from soy. The delivered doses of genistein (1, 2, 4, 8, or 16 mg/kg body wt) were higher than those previously administered to humans. Formulation A was composed of 90 ± 5% genistein, 10% daidzein, and 1% glycitein. Formulation B was composed of 43% genistein, 21% daidzein, and 2% glycitein. Results: We observed no clinically significant behavioral or physical changes after treatment. We observed elevations in lipoprotein lipase and hypophosphatemia that were possibly related to the treatment but that were associated with no clinical toxicity. Considerable quantities of isoflavones were excreted in urine as conjugates. The terminal elimination rate, elimination half-life, area under the curve, maximum plasma concentration, apparent systemic clearance, and volume of distribution were estimated for genistein and daidzein. The mean elimination halflives with both formulations were 3.2 h for free genistein and 4.2 h for free daidzein. The mean pseudo half-lives were 9.2 h for total genistein and 8.2 h for total daidzein. Conclusions: Dietary supplements of purified unconjugated isoflavones administered to humans in single doses exceeding normal dietary intake manyfold resulted in minimal clinical toxicity. Genistein and daidzein (free and total) were rapidly cleared from plasma and excreted in urine. Am J Clin Nutr 2002;75:126‐36. |
| Databáze: | OpenAIRE |
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