The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria
| Autor: | Keiji Isshiki, Shin-ichi Araki, Hiroshi Maegawa, Ryuichi Kikkawa, Atsunori Kashiwagi, Yasuo Kida, Daisuke Koya, Takashi Uzu, Masakazu Haneda, Shinji Kume, Atsushi Yamauchi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Blood Pressure Kaplan-Meier Estimate Type 2 diabetes Risk Factors Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies Aged Kidney Proteinuria medicine.diagnostic_test Cerebral infarction business.industry Type 2 Diabetes Mellitus Magnetic resonance imaging Cerebral Infarction Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Blood pressure medicine.anatomical_structure Diabetes Mellitus Type 2 Disease Progression Albuminuria Cardiology Kidney Failure Chronic Female medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of the American Society of Hypertension. 6:124-131 |
| ISSN: | 1933-1711 |
| Popis: | There is little evidence regarding the target blood pressure level in patients with type 2 diabetes mellitus without overt proteinuria.We followed 608 Japanese patients with type 2 diabetes without apparent cardiovascular disease and overt proteinuria who underwent cerebral magnetic resonance imaging for a mean of 7.5 years. The patients were categorized according to their mean systolic blood pressure during the follow-up period (strict:130 mm Hg, moderate: ≥130 and140 mm Hg, poor: ≥ 140 mm Hg). The risks for the primary composite outcome of death or end-stage renal disease were not different among the three groups. The renal risk of the doubling of serum creatinine for the poor group was significantly higher than those in other groups. In addition, among the patients without silent cerebral infarction (SCI), the renal risk was significantly lower in the strict group than in the moderate group. Further, in both the SCI and non-SCI groups, strict blood pressure control slowed the progression of albuminuria.In nonproteinuric diabetic patients without SCI, strict blood pressure control was associated with improved renal outcomes. There may be different effects of intensive blood pressure control on the renoprotection of diabetic patients according to their complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|