A case of monofocal motor neuropathy with GM1 and GD1b antibodies improved with intravenous immunoglobulin
| Autor: | Antonio Cappello, Paolo Borelli, Andrea Salmaggi, Andrea Rigamonti, Paola Basilico, Vittorio Mantero |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Weakness Pathology medicine.medical_specialty Igm antibody Immunology Pathogenesis Mononeuropathy 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy biology business.industry medicine.disease Middle age 030104 developmental biology Neurology biology.protein Neurology (clinical) medicine.symptom Antibody business Motor neuropathy 030217 neurology & neurosurgery Multifocal motor neuropathy |
| Zdroj: | Journal of Neuroimmunology. 350:577452 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2020.577452 |
| Popis: | Multifocal motor neuropathy is a purely motor neuropathy with a probably dysimmune pathogenesis, supported by the presence of anti-GM1 IgM antibodies in about half of the cases. Single nerve involvement allows for diagnosis of possible multifocal motor neuropathy. We present the case of a middle age man presenting with progressive weakness and hypotrophy in the left leg and difficulty in walking, in which we have diagnosed a dysimmune mononeuropathy. Treatment with IVIg was performed with substantial improvement. Although only one nerve is involved, early diagnosis of dysimmune mononeuropathy is important to start IVIg treatment that is often decisive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect